The integration of chelated minerals into aquaculture diets represents a significant advancement in enhancing the health and productivity of aquatic species. These minerals improve nutrient bioavailability, boost immune responses, and increase disease resistance in fish and shrimp, effectively addressing key challenges in aquaculture sustainability. This review highlights the benefits of chelated minerals, including their role in improving feed efficiency, promoting resilience against infections, and mitigating heavy metal toxicity. Key findings indicate that chelated minerals enhance nutrient absorption, which is crucial for optimizing growth and overall health. Furthermore, they strengthen immune responses, thereby increasing resilience to diseases in aquaculture environments. Additionally, these minerals boost antioxidant capacity, helping to alleviate oxidative stress caused by environmental factors and pathogens. The review emphasizes the need for further research to optimize the use of chelated minerals, focusing on mechanisms of action, species-specific responses, and long-term impacts on ecosystems. Successful implementation will require collaboration among researchers, nutritionists, and practitioners to develop evidence-based guidelines for their responsible use. In conclusion, the incorporation of chelated minerals into aquaculture diets has the potential to revolutionize practices and significantly improve the welfare of aquatic species.