Nec-1 regulates phenotypic transformation of heat stroke-induced vascular smooth muscle cells by inhibiting RIPK1.

• Tác giả: Ling Hou, Guanghua Li, Le Mu, Wei Tuo, Xiaomin Wu, Shujing Xue
• Ngôn ngữ: eng
• Ký hiệu phân loại: 959.57 *Singapore
• Thông tin xuất bản: England : International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group , 2025
• Bộ sưu tập: NCBI
• ID: 644055
• Chủ đề: 1. Nec; 2. 1; 3. Regulates

Tóm tắt

OBJECTIVE: Cardiovascular injury is a common complication of heat stroke (HS). However, the mechanism underlying vascular smooth muscle cells (VSMCs) following HS remains unclear. METHOD: A rat and VSMCs model was established by simulating high-temperature exposure. Primary VSMC was extracted RESULTS: The results of CONCLUSION: HS induces abnormal phenotypic transformation and necroptosis in VSMCs. Necrostatin-1 can improve necroptosis and maintain the contractile phenotype of VSMCs. This study can provide new insights into cardiovascular damage caused by high temperatures.