Transposable elements may enhance antiviral resistance in HIV-1 elite controllers.

• Tác giả: Matthew L Bendall, Cédric Feschotte, Luis Pedro Iñiguez, Sabrina M Leddy, Douglas F Nixon, Manvendra Singh
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.13437 Aerospace engineering
• Thông tin xuất bản: England : Genome biology , 2025
• Bộ sưu tập: NCBI
• ID: 644300

Tóm tắt

BACKGROUND: Less than 0.5% of people living with HIV-1 are elite controllers (ECs)-individuals who maintain undetectable plasma viremia without antiretroviral therapy, despite having replication-competent viral reservoirs. While EC CD4 RESULTS: We find the CD4 CONCLUSIONS: We propose that the EC phenotype is driven in part by reduced KZNF-mediated repression of specific TE-derived cis-regulatory elements for antiviral genes, heightening their resistance against HIV-1. Our study reveals heterogeneity in the EC CD4