SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis.

• Tác giả: Ying Chen, Ruiwu Dai, Ya-Nan Deng, Lan Huang, Qiu Li, Shufang Liang, Shu Luo, Yinheng Luo, Zenghua Sheng, Nan Zhang, Xinyu Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.4226 Research; statistical methods
• Thông tin xuất bản: England : Oncogene , 2025
• Bộ sưu tập: NCBI
• ID: 644317

Tóm tắt

Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex by employing protein co-immunoprecipitation enrichment in combination with His