Management Strategies of Neurofibromatosis Type 2 in Pediatric Patients : Challenges and Emerging Therapies.

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Tác giả: Jong Seok Lee

Ngôn ngữ: eng

Ký hiệu phân loại: 615.54 Pediatric and geriatric therapeutics

Thông tin xuất bản: Korea (South) : Journal of Korean Neurosurgical Society , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 644382

Neurofibromatosis type 2 (NF2) is a rare genetic disorder caused by mutations in the NF2 tumor suppressor gene, characterized by bilateral vestibular schwannomas (VSs) and other central and peripheral nervous system tumors. Pediatric patients often present with more aggressive disease, greater tumor burdens, and increased morbidity compared to adults. Management requires a multidisciplinary approach that balances tumor control with functional preservation. While surgery and radiosurgery remain key treatment options, they carry risks such as hearing loss and malignant transformation of existing tumors. Bevacizumab and emerging therapies like gene therapy show promising therapeutic effects but are limited by variability in efficacy. Comprehensive care, including psychosocial support, is essential to improve clinical outcomes and quality of life for children with NF2.
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