Constructing multimetallic alloy heterostructures with the desired interface and phase separation is a promising method to optimize the electrochemical properties of noble metal nanomaterials. Nevertheless, tailoring the elemental distribution and lattice structures of such multimetallic nanomaterials still poses major difficulties. In this study, Cu-PtNi nanowires coupling PtNi with PtNiCu active sites are fabricated by seeded synthesis on a Cu template. Owing to the oxophilic nature of PtNi sites and the anti-CO poisoning capability of PtNiCu facets, the as-synthesized Cu-PtNi nanowires exhibit enhanced methanol oxidation reaction (MOR) performance (7.73 A mg