Some N-alkylisatins were synthesized using alkylation reaction of isatin by different alkyl halides in DMF in presence of K2CO3 in microwave oven. These N-alkylisatins were converted to corresponding thiosemicarbazones by reaction with 4-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)thiosemicarbazide using microwave-assisted heating method. The structures of products have been confirmed by IR, NMR and mass spectra.