By cyclization reaction of 1-acetyl-2-hidroxynaphthalene with anhydride acetic to get 3-acetyl-2methylbenzo[f]chromone. The product was then transformed by condensation with aromatic aldehydes to form a series of new alpha,beta-unsaturated ketones (7 compounds) and (2-arylvinylbenzo[f]chromone-3-yl)aryl vinyl ketones (4 compounds). Structure of the obtained products were confimed by 1R, 1H NMR, 13C NMR, HSQC, HMBC and MS spectroscopic data. The biological activities of these compounds have been investigated.