In the period from June 2010 to June 2011, 637 patients admitted for surgery at Da Nang C hospital were assessed for wound infection. The overall infection rate was 4.71 percent. The usage rate of prophylaxis antibiotics in surgery department was quite high, 93.5 percent. The most common isolate were Staphylococcus, Pseudomonas Aeruginosa, E. Coli/Proteus Mirabilisl Enterococcus sp.