The four isolated samples C. cassiicola (CoryLK02, CoryPK01, CoryLK26 and CoryLK38), representing 2 genetic groups and different host sources in Vietnam, were selected to test their pathogenicity using artificial inoculation on 7 rubber clones, papaya and white pumpkin in greenhouse condition. The infection level of 4 representative isolates on 7 rubber clones, papaya and white pumpkin after 10 days of inoculation showed from no any symptom to clear symptoms on some rubber clones such as RRIV 3 and RRIV 4. The percent disease intensity was from 0.0 to 57.6 percent and the average infection score varned from 0.0 to 2.9 respectively, all of the representative isolates could infect on leaves of rubber clones. CoryLK02 isolate caused slight infection on papaya and white pumpkin, but the CoryPK01 isolate does not showed any symptom on these hosts. The isolate CoryLK26 was pathogenic on papaya and caused slight disease on all of the rubber clones in this study. While the CoryLK38 isolate was not only pathogenic on white pumpkin but also on rubber tree and papaya.