How could quercetin exert a pro-survival phenotype (antioxidant) and simultaneously be toxic for eukaryotic cells? The redox capacity of quercetin may explain its antioxidant and toxic effects, based on the idea that quercetin impairs the electron transport chain, affecting ATP production and forming quercetin-derived free radicals. Herein, we provide evidence that quercetin supplementation: (1) depolarizes the mitochondrial membrane and augments the ADP/ATP ratio
(2) increases superoxide anion cellular levels
(3) changes the cellular response to H