Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis.

• Tác giả: Jacqueline Boultwood, Pak Leng Cheong, Hamid Dolatshad, Douglas R Higgs, Juseong Lee, Andrea Pellagatti, Shalini Singh, Tianyu Sun, Hayson Chenyu Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.73 Artillery installations
• Thông tin xuất bản: England : British journal of haematology , 2025
• Bộ sưu tập: NCBI
• ID: 649944

Tóm tắt

We sought to identify new candidate drugs for repurposing to myelodysplastic syndromes (MDS). Connectivity map analysis was performed on gene expression signatures generated from bone marrow CD34