Objective: The study was carried out at Haiphong Children Hospital to describe some epidemiologic and clinical features and laboratory findings of newborns with unconjugated bilirubinemia in 2013. Objects and Method: Objects included 37 heavy unconjugated bilirubinemia and method was descriptive and cross-sectional study. Results and Conclusions: More males (59.5 percent) than females (40.5 percent) affected the disease males. Terms hospitalized the most in the third days after birth, preterm in the first day after birth. Average day of jaundice was 2.11 +/- 1.02 days. Jaundice was also the main reason from hospitalization 77.7 percent. On admission, patients showed whole body jaundice, breathing disorder, and legarthy (77.7 percent, 67.6 percent, and 40.5 percent respectively). Preterm was the most common accompanied disease, there was a strong association between high free Bilirubinemia and legarthy, cyanosis crise (p0.005). The main cause of jaundice was maternofoetal incompatibility of ABO blood system (18/37). There was not Rh system incompatibility. The free Bilirubinemia concentration increased according to days of age (p0.001). Coombs Test antibody titres contributed to indentifying the cause of ABO system incompatibility in jaundice newborns.