Objective: Creating prefabricated flaps using tissue expanders in combination with implantation of maximal blood flow vascular pedicles into suitable tissue areas represents a new tendency in the reconstruction of large skin defects. Subject and method: In 42 Chinchilla Bastard weighing from 3700g to 4600g, skeletonized arteriovenous pedicles with maximal blood flow dissected from the femoral and saphena magna bundles were implanted underneath abdominal fasciocutaneous flaps. Oval tissue expanders of 250ml were placed and fixed on the abdominal wall to expand these prefabricated flaps. The evaluation parameters were macroscopic observation, blood analysis, selective microangiography, histology and scintigraphy. Result: The study results showed that neovascularization in expanded prefabricated flaps was established from the newly formed vessels generated from the implanted pedicles and their vascular connections with the originally available vasculature in the flap. After 20 days of prefabrication, the entire expanded prefabricated flaps were perfused by the blood flow supplied from the newly implanted arteriovenous pedicles. Conclusion: The study indicated that flap expansion can be successfully created by the implantation of a maximal blood flow pedicle in random-pattern flap.