Age at menopause and cognitive function and decline among middle-aged and older women in the China Health and Retirement Longitudinal Study, 2011-2018.

• Tác giả: Alden L Gross, Muqi Guo, Carrie Karvonen-Gutierrez, Lindsay C Kobayashi, Yingyan Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 996.9042 North central Pacific islands Hawaii
• Thông tin xuất bản: United States : Alzheimer's & dementia : the journal of the Alzheimer's Association , 2025
• Bộ sưu tập: NCBI
• ID: 65389

Tóm tắt

 INTRODUCTION: Chinese women experience higher dementia rates than men, yet sex-specific risk factors are understudied. We examined how menopause age affects cognitive function and decline in aging Chinese women. METHODS: Data were from 7419 postmenopausal women 45-101 years of age at baseline in the China Health and Retirement Longitudinal Study (CHARLS
  2011-2018). Menopause age was categorized using clinical cutoffs (<
 40, 40-44, 45-49, 50-55, >
 55 years). Cognitive function was assessed with neuropsychological tests up to four times over 7 years, and associations were analyzed using multivariable-adjusted linear mixed-effects regression. RESULTS: Compared to menopause at 50-55 years (3661/7419
  49.3%), premature (<
 40
  235/7419
  3.2%), early (40-44
  623/7419
  8.4%), and late menopause (>
 55
  366/7419
  4.9%) were associated with lower baseline cognitive scores. Although the rate of cognitive decline did not differ significantly across menopause age groups, late menopause showed a trend toward faster decline. DISCUSSION: Cognitive health interventions should consider extreme menopausal age as a risk factor. HIGHLIGHTS: Extreme menopausal ages-premature (<
 40), early (40-44), and late (>
 55)-are linked to lower baseline cognition versus menopause ages 50-55, persisting over 7 years. Cognitive disadvantage for late menopause (>
 55) versus 50-55 tends to increase over time. Health interventions should consider extreme menopause ages in women's cognitive health.