Chế tạo, đặc trưng và hình thái cấu trúc của màng chitosan mang nifedipine

• Tác giả: Thị Thu Trang Nguyễn, Thúy Chinh Nguyễn, Hoàng Thái, Thị Mai Trần
• Ngôn ngữ: vie
• Ký hiệu phân loại: 615.92 Inorganic poisons
• Thông tin xuất bản: Khoa học và Công nghệ, 2015
• Mô tả vật lý: 637-645
• Bộ sưu tập: Metadata
• ID: 654668

Tóm tắt

This paper presents some characters and morphology of films based on chitosan (CS) and nifedipine (NIF) with various NIF content prepared by solution method. The characteristic peaks of some groups in CS and NIF in Fourier transform infrared spectroscopy (FTIR) spectra of the CS/NIF films shift slightly in comparison with that in the FTIR spectra of CS and NIF. This proved that CS and NIF were interacted with each other. NIF dispersed in the CS matrix with the relatively small size from 200 nm to 2 um. Thermal analysis results showed that the CS/NIF films have less thermostable than the CS. The calibration equations of NIF were set up from data of UV-Vis spectra and regression coefficients obtained higher than 0.996. In vitro release study of CS/NIF films indicated drug release rate was almost higher in pH 7.4 solution than that in pH 6.8 solution for the samples containing 10, 30 and 50 wt percent NIF.