Pulmonary disorders are currently the major cause of morbidity and mortality in systemic sclerosis. The purpose of the study was to explore the characteristics of clinical and sub-clinical scleroderma with interstitial pulmonary disease. Methods: A cross-sectional study was conducted in 37 patients diagnosed with systemic sclerosis from November to August at the Center for Allergy and Clinical Immunology, Bach Mai Hospital. Results: Clinical symptoms are shortness of breath, dry cough, chest pain, fever and rale. Subclinical sign from high - resolution computer tomography (CT scan) shows 84 percent of the study population has interstitial lung disease, 45.9 percent has mixed disorder lung function and 21.6 percent has restrictive disorder
most of them are mild and moderate. There is a significant correlation between interstitial lung disease and FVC, FEV1, anti-topoisomerase antibodies (anti - Scl - 70). Conclusions: Interstitial lung disease is a common disorder in systemic sclerosis. the authors found a strong association between restrictions in pulmonary lung function and positive anti - topoisomerase antibodies.