Objective: To assess the value of Ki-67 in ameloblastomas and to correlate this with histopathology. Subject and method: Thirty-five archival tissue sections of ameloblastomas were immunohistochemically stained with Ki-67 antisera. Immunoreactivity was evaluated by the counting of cells (Labelling Index LI). All the data about this and histopathology obtained were statistically analyzed. Result: In this study, the specimens comprised of 15 cases of male (42.9 percent) and 20 cases of female (57.1 percent). The mean Ki-67 LI of ameloblastomas was 12.9 +/- 8.4. The solid/multicystic ameloblastomas exhibited significantly higher Ki-67 LI (15 +/- 8.8) than unicystic ameloblastomas (8.2 +/- 4.1) or desmoplastic ameloblastomas (6 +/- 2.6) (p0.05). Furthermore, the Ki-67 LI of follicular type and plexiform type was 15.9 +/- 8.5 and 15.5 +/- 11, respectively. Conclusion: There was a statistically significant correlation between Ki-67 LI and histopathologic features of ameloblastomas.