Objective: In this study, the authors analysed the diagnosis and treatment of pulmonary sequestration (PS) in 19 adult patients at a single institution. Subject and method: A retrospective review of all adult patients with pulmonary sequestration in a single institution from June 2009 to august 2014 was conducted. The following data were analyzed for all patients: Major symptoms, diagnostic procedures, operative findings, operative techniques, postoperative complications and outcome. Result: the study involved 19 patients, 7 males and 12 females, with an average age of 29.3 (19-52) years, who underwent surgical intervention for pulmonary sequestration. The preoperative symptoms of these patients included cough, fever, chest pain, asymptomatic. Fifteen, (78.9 percent) patients were diagnosed by thoracic computed tomography. Surgical procedures for pulmonary sequestration included lobectomy in twelfth patients, VATS lobectomy in four and VATS mass excision in three patients. One patient had a postoperative complication (prolonged air leak). The average hospital stay for all study patients was 7.8 (6-12) days, and there was no mortality. Conclusion: Diagnostic tools may enable the clinician to obtain a definitive diagnosis in patients where there is a strong suspicion of pulmonary sequestration via a noninvasive procedure. CT, MSCT or MRI is powerful noninvasive technique for the detection of pulmonary sequestration. Resection of the involved lung leads to excellent results and highly favorable long-term outcome.