Objective: Evaluating the change in hemodynamic and respiratory, circulatory status of potential brain dead donors following directed resuscitation based on PiCCO. Subject and method: 44 patients (1664 years), diagnosed according to the criteria of brain death, is treated according to management guidelines based on hemodynamic parameters PiCCO (transpulmonary thermodilution) aims to evaluate the change in hemodynamic and respiratory, circulatory status of potential brain dead organ donor. Record hemodynamic parameters through PiCCO, respiratory function, SOFA score on to (confirmed diagnosis of brain death), t1, (after 12 hours), t2 (after 24 hours), t3 (after 36 hours), t4 (after 48 hours), t** (before surgery). Result: 24 donors, 32/44 patients achieved the goal PiCCO after 12 hours of resuscitation, 11/20 after 24 hours, after 36 hours have 10/20 at the goal, but with many other disorders. Conclusion: Of cadaveric patient's hemodynamic is stable 12-24 hours after definitive diagnosis and resuscitation of brain death cases.