Objective: To compare the time of anaesthesia induction, recovery and extubation, the impact on blood-pressures and heart rates after propofol and sevofluran administration and anaesthetic level adjustment according to electro-encephalogram (EEG) Entropy. Subject and method: A prospective crosssectional descriptive study on patients aged from 16 to 65, ASA 1-2, who underwent endotracheal anesthesia for planned surgery (operation time more than one hours) at Department of Anesthesiology, Viet Tiep hospital in Hai Phong. Patients were divided into 2 groups: Group I: Sevorane anesthesia, group II: Propofol anesthesia. Result: The induction time of propofol group were shorter than that of sevofluran group (95.55 +/- 25.90 seconds versus 130.01 +/- 35.45 seconds) with p0.05. The recovery and extubation time of propofol group were longer than those of sevofluran group (13.65 +/- 8.00 and 15.90 +/- 8.90 minutes versus 10.05 +/- 6.02 and 14.05 +/- 6.85 minutes, respectively) with p0.05. There was no difference in mean heart rates and blood-pressures between 2 groups at 3 anesthetic levels A, B, C. Conclusion: The anaesthesia induction time of propofol using TCI technique was statisticantly significantly shorter but the recovery and extubation time were longer than those of Sevoflurane with p0.05. There was no difference in mean heart rates and blood-pressures between 2 groups at 3 anesthetic levels. The RE, SE values gradually decreased in concordance with the anesthetic levels. At the same anaesthesia level, there was no statistically significant difference in RE, SE and RE-SE values between 2 groups. Therefore, Electroencephalogram (EEG) has equivalent value in anaesthesia with propofol and Sevoflurane at all anesthetic level and is the standard parameter to monitor and adjust the anesthetic level.