POEMS syndrome is a rare para-neoplastic disorder due to an underlying plasma cell dyscrasia with five main features: polyneuropathy, organomegaly, endocrinopathy, monoclonalgammopathy, and skin changes. In Viet Nam, not many cases of POEMS syndrome has been reported. Here the authors report and discuss a 28-year-old female patient diagnosed with POEMS syndrome and treated at the Neurology Department, No.108 Military Central Hospital.