The availability of mental health services in the Dominican Republic is limited and mental health needs have increased since the onset of the COVID-19 pandemic. Mobile mental health apps may be a feasible response to this increased demand for services, but few have been tested in Spanish speaking low- and middle-income countries. The objective of this study was to evaluate the effectiveness of a mobile app, El Buen Consejo Movil (EBCM) to reduce symptoms of anxiety, depression, social isolation and loneliness. Of the twenty-seven participants who screened eligible to use EBCM, twenty participants logged in and used the app (users). The PHQ-9 results were clinically and statistically significant. A decrease in PHQ-9 score was sustained in 75% of users over 12 weeks. Results of the pre and post NIH Toolbox Adult Social Relationship Scales indicated that there was a statistically significant difference in score (p = .011). Our study is one of the few studies to trial a mobile app in a Spanish speaking Caribbean LMIC. The EBCM app was a useful and effective resource to support the therapeutic process for participants with symptoms of depression.