Background: Medication adherence is important for success of nucleos(t)ide analogue (NA) treatment for chronic hepatitis B (CHB). The aims of this study were to describe the reason of poor adherence of CHB patient and the effect of the poor adherence to CHB treatment. Methods: Using the describe cross - sectional study design
the authors randomly selected 126 eligible patients, monitor patients' medication adherence by the question and count the remaining monthly tablet. Results: In 126 CHB patients, 92 persons reported 100 percent adherence (73 percent)
34 patients reported poor adherence (27 percent). In the group with 100 percent adherence, 27/34 patients quit voluntarily because they have not understood the importance of NA adherence. Those who live with their spouses, have used measures are reminded to take better compliance with the other group. Besides the long treatment duration or = 24 months also affect treatment compliance. Biochemical response, viral response and sero-conversion rate of the group with 100 percent adherence was significantly higher than the group poor adherence (p 0.05). Conclusions: The rate of poor adherence in CHB patients was 27 percent. Poor adherence will lead to poor outcome treatment. The data highlight the importance of education on medication adherence to improve the effectiveness of HBV treatment in clinical practice and provide insights into how adherence may be augmented.