Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis.

• Tác giả: P Heeringa, T Kissel, S Reijm, M Rizzi, A Rutgers, H U Scherer, E M Stork, Yko Teng, Rem Toes, L A Trouw, R van de Wetering, D van der Woude, K A van Schie, N Venhoff, R E Voll, C M Wortel
• Ngôn ngữ: eng
• Ký hiệu phân loại: 635.41 *Spinach
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 66133

Tóm tắt

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a prototypic autoimmune disease, with a subset of AAV patients manifesting anti-myeloperoxidase (MPO) IgG. Patients with AAV respond positively to B cell-targeting and complement-targeting therapies, but disease flares are not uncommon. Here, by comparing samples from healthy individuals and MPO