Hypervalent Iodine(III)-Mediated Oxidative Cyclization of Exo-Cyclic Ene-Carbamate to Tetrahydroisoquinoline-Oxazol-2(3H)-one Derivatives.

• Tác giả: Winai Ieawsuwan, Suphaporn Limjirawatthana, Poonsakdi Ploypradith, Somsak Ruchirawat, Chatphorn Theppitak
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.4226 Research; statistical methods
• Thông tin xuất bản: Germany : Chemistry, an Asian journal , 2025
• Bộ sưu tập: NCBI
• ID: 661616

Tóm tắt

The new development of a transition-metal-free method for the synthesis of THIQ-oxazol-2(3H)-one motif from exo-cyclic ene-carbamates by using hypervalent iodine as an oxidant is reported. Various functional groups substituted on the aryl rings of the ene-carbamate substrates as well as the N- and S-heterocyclic substrates afforded the corresponding THIQ-oxazol-2(3H)-one products in up to 91% yield. Moreover, the synthetic utility was highlighted for the synthesis of phthalide-THIQ natural product, (±)-corlumine.