Methionine Restriction Exerts Anti-Tumor Immunity via Joint Intervention of T-Bet Palmitoylation in Gastric Cancer.

• Tác giả: Luo-Jun Fan, Jin-Heng Gan, Chuan Liu, Jiang Liu, Lin Xin, He-Song Xu, Zhen-Qi Yue, Qi Zhou, Yong-Hui Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 069.2 Management and use of physical plant
• Thông tin xuất bản: Germany : Biotechnology journal , 2025
• Bộ sưu tập: NCBI
• ID: 661625

Tóm tắt

BACKGROUND: Methionine restriction (MR) exerts an anti-tumor immunomodulatory role. Th1 cells facilitate CD8 METHODS: Murine Foregastric Carcinoma (MFC) cells were injected into 615 mice to establish transplanted tumor models, which were then treated with an MR diet or combined with 2-bromopalmitate (2-BP). CD4 RESULTS: MR enhanced anti-PD-1's inhibition of tumor growth, while concurrently suppressing the increased Th1 cells. Combined with 2-BP further inhibited tumor and increased Th1 cells. Suppressing Th1 activity attenuated 2-BP's synergistic therapeutic effect and reduced CD8 CONCLUSIONS: MR combined with T-bet palmitoylation intervention promotes Th1 polarization and CD8