Survival and Developmental Progression of Unselected Thymocytes in the Absence of the T-Cell Adaptor Gads.

• Tác giả: Enas Hallumi, Naama Klopstock, Manal Marzouk, Rose Shalah, Deborah Yablonski
• Ngôn ngữ: eng
• Ký hiệu phân loại: 338.9 Economic development and growth
• Thông tin xuất bản: Germany : European journal of immunology , 2025
• Bộ sưu tập: NCBI
• ID: 662123

Tóm tắt

Thymocyte β-selection and positive-selection depend on TCR signaling via the immune adaptors SLP-76 and LAT. Gads bridges the recruitment of SLP-76 to LAT, yet is not required for the maturation of single positive (SP) thymocytes. To illuminate this paradox, we performed tamoxifen-induced ablation of Gads (Gads