Recently, the enzyme-inspired nanoconfinement effect has garnered significant attention for enhancing the efficiency of electrocatalysts and photocatalysts. Despite substantial progress in these fields, there remains a notable absence of comprehensive and insightful articles providing a clear understanding of nanoconfined catalysts. This review addresses this gap by delving into nanoconfined catalysts for electrocatalytic and photocatalytic energy conversion. Initially, the effect of nanoconfinement on the thermodynamics and kinetics of reactions is explored. Subsequently, the primary and secondary structures of nanoconfined catalysts are categorized, their properties are outlined, and typical methods for their construction are summarized. Furthermore, an overview of the state-of-the-art applications of nanoconfined catalysts is provided, focusing on reactions of hydrogen and oxygen evolution, oxygen reduction, carbon dioxide reduction, hydrogen peroxide production, and nitrogen reduction. Finally, the current challenges and future prospects in nanoconfined catalysts are discussed. This review aims to provide in-depth insights and guidelines to advance the development of electrocatalytic and photocatalytic energy conversion technology by nanoconfined catalysts.