Nanocapsules with dual-targeting of cell and mitochondria functions for enhanced hypoxia-activated drug therapy.

• Tác giả: Yingshu Guo, Fen Li, Ziyi Li, Mengting Wu, Qingqing Zhang, Jing Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.453 Tin
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 662310

Tóm tắt

The cell and mitochondria dual-targeting nanocapsules reported here could exacerbate tumor hypoxia to activate a hypoxia-activated drug, tirapazamine, producing benzotriazinyl radicals and ˙OH, which are capable of killing tumor cells