Loss of TRPV4 decreases NFκB-mediated myometrial inflammation and prevents preterm labor.

• Tác giả: Cristina M Alvira, David N Cornfield, Daiana Fornes, Xiaoyuan Han, Judith A Ingles, Zahidee Rodriguez, Lihua Ying
• Ngôn ngữ: eng
• Ký hiệu phân loại: 335.433 Trotskyist doctrines
• Thông tin xuất bản: United States : FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2025
• Bộ sưu tập: NCBI
• ID: 663662

Tóm tắt

Inflammation is a key initiating event in both spontaneous term and preterm labor. However, the link between inflammation and the onset of labor remains incompletely understood. We identified the transient receptor potential vanilloid 4 (TRPV4) channel as a critical regulator of myometrial calcium (Ca