In the multi-objective optimization design of automotive seats based on Approximation-Based Design Optimization, a single approximation model may not adequately address the requirement of accurately fitting highly nonlinear feature data. For this reason, the Hybrid Approximation Models based on the Multi-Species Approximation Model (HAM-MSAM) is proposed to meet the requirement for high fitting accuracy. Subsequently, this study introduces a HAM-MSAM-based Approximation-Based Global Multi-Objective Optimization Design (ABGMOOD) strategy. This strategy is employed in the multi-objective optimization of the rear seat of a passenger car. HAM-MSAM was constructed from an experimentally validated finite element model and a training set generated through experimental design. The advantages of HAM-MSAM in capturing the highly nonlinear response under seat crash conditions were validated through comparison with hybrid model construction methods reported in existing literature. Finally, the optimization results obtained by the ABGMOOD strategy were compared to those of the classical local multi-objective optimization strategy, demonstrating the substantial advantages of the ABGMOOD optimization scheme in economy and weight reduction. In addition, the safety of the rear seats is slightly lower than that of the local optimization scheme but remains in compliance with regulatory requirements. The final optimized rear seat demonstrates notable improvements in safety, economy, and weight reduction, validating the feasibility of the ABGMOOD strategy and providing valuable insights for similar engineering optimization challenges.