Instability of high polygenic risk classification and mitigation by integrative scoring.

• Tác giả: Akl C Fahed, Anika Misra, Pradeep Natarajan, Aniruddh P Patel, Jordan W Smoller, Yang Sui, Buu Truong, Sarah M Urbut
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 66425

Tóm tắt

Polygenic risk scores (PRS) continue to improve with novel methods and expanding genome-wide association studies. Healthcare and commercial laboratories are increasingly deploying PRS reports to patients, but it is unknown how the classification of high polygenic risk changes across individual PRS. Here, we assess the association and classification performance of cataloged PRS for three complex traits. We chronologically order all trait-related publications (Pub