To report a case of calcific band keratopathy (CBK) secondary to multiple myeloma (MM) successfully treated with phototherapeutic keratectomy (PTK). An 80-year-old woman presented with progressive vision loss in her left eye with a best corrected visual acuity (BCVA) of 4/10 in the left eye (OS). Slit-lamp examination revealed a central band-like corneal opacification indicative of CBK. Anterior segment optical coherence tomography (AS-OCT) showed a subepithelial hyper reflective layer. Further evaluation confirmed an indolent IgAk MM, with no indication for systemic therapy. PTK was performed using the Technolas® TENEO™ 317 M2 excimer laser, resulting in corneal surface regularization and BCVA improvement. At 1-year follow-up, the patient was asymptomatic, had a clear cornea, normal topography, and a BCVA of 10/10. CBK can be associated with systemic conditions. PTK is an effective and safe procedure for managing CBK, and can provide complete visual rehabilitation.