Biological Evaluation of Molecular Spherical Nucleic Acids: Targeting Tumors via a Hybridization-Based Folate Decoration.

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Tác giả: Antti Äärelä, Anu J Airaksinen, Putri Andriana, Tatsiana Auchynnikava, Imran Iqbal, Toni Laine, Jyrki Lehtimäki, Heidi Liljenbäck, Olli Moisio, Senthil Palani, Johan Rajander, Anne Roivainen, Harri Salo, Pasi Virta

Ngôn ngữ: eng

Ký hiệu phân loại: 591.4 +Physical adaptation

Thông tin xuất bản: United States : ACS omega , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 667102

Folate receptors (FRs), membrane-bound proteins that bind specifically to folate with high affinity, are overexpressed by various cancer types and are therefore used as targets for delivery of therapeutic agents. Molecular spherical nucleic acids (MSNAs) are dendritic formulations of oligonucleotides (ONs) that may have advantages over linear parent ONs with respect to delivery properties. Here, we assembled folate-decorated MSNAs, site-specifically radiolabeled them, and then biologically evaluated their effects in mice bearing HCC1954 breast cancer xenograft tumors. The biodistribution of intravenously administered
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