Metal-Free, Visible-Light-Mediated Synthesis of Tetracyclic Benzimidazole: Regioselective C-H Functionalization with In Vitro and Computational Study of Anti-breast Cancer Compounds.

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Tác giả: Chandu Ala, Kishor H Chikhalia, Annu Choudhary, Nachiket Dattatray Garge, Kamlesh K Gurjar, Sudeshna Mukherjee, Bimalkumar Patel, Hitesh D Patel, Vipul P Patel, Murugesan Sankaranarayanan

Ngôn ngữ: eng

Ký hiệu phân loại: 618.92097 Pediatrics and geriatrics

Thông tin xuất bản: United States : ACS omega , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 667167

Globally, breast cancer is the leading cause of mortality. Within the field of antibreast cancer drug design by several compound docking studies, eight new N-containing nonsteroid tetracyclic derivatives have been synthesized via regioselective intramolecular C-H functionalization by visible light. The adopted methodology is highly efficient, green, and sustainable to unload a new pathway with excellent yield. It offers a rapid, low-cost, catalyst-free method for creating physiologically active molecules from easily accessible substrates. The synthesized substances were described using spectroscopic methods like HRMS,
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