Doxycycline-Loaded pH-Sensitive Microparticles as a Potential Site-Specific Drug Delivery System against Periodontitis.

• Tác giả: Syaiful Choiri, Nurul Fauziah, Rafikah Hasyim, Nasyrah Hidayati, Aqilah Fidya Madani, Ulfah Mahfufah, Karima Qurnia Mansjur, Ardiyah Nurul Fitri Marzaman, Maria Mir, Nur Aisyah Nuzulia, Andi Dian Permana, Dian Setiawati, Fadhlil Ulum Ar Rahman
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS omega , 2025
• Bộ sưu tập: NCBI
• ID: 667441

Tóm tắt

A significant obstacle to the healing process of periodontitis is the development of bacterial biofilms within the periodontal pockets. The efficacy of bacterial biofilm therapy is often hindered by the inadequate penetration of antibacterial agents and the nonspecific targeting of bacteria. This study proposes a novel strategy involving the utilization of pH-sensitive microparticles (MPs) of doxycycline (DOX) to enhance biofilm penetration and enable targeted delivery of DOX to infection sites associated with periodontitis. The MPs were developed using a double-emulsion technique with poly(d,l-lactide-