3,3'-Diindolylmethane (DIM): A Molecular Scaffold for Inhibition of WWP1 and WWP2, Members of the NEDD4 Family HECT E3 Ligases.

• Tác giả: Jesus Angulo, Andrew Chantry, Ashley P Dudey, Andrew M Hemmings, Gregory R Hughes, Serena Monaco, Jake M Rigby, G Richard Stephenson, Thomas E Storr
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS omega , 2025
• Bộ sưu tập: NCBI
• ID: 667445

Tóm tắt

Indole-3-carbinol (I3C) is a metabolic derivative of glucobrassicin found in cruciferous vegetables. Known for its anticarcinogenic properties, I3C has been shown to target the NEDD4 family HECT E3 ligases, NEDD4-1 and WWP1, yet