MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation.

• Tác giả: Dominique Armstrong, Brianna Burns, Alexandre Carisey, Benjamin Casal, Cheng-Yen Chang, David B Corry, Chad J Creighton, William Decker, Linda Green, Monica J Hong, William Hudson, Sheetal Jammi, Sung Wook Kang, Farrah Kheradmand, Hyun-Sung Lee, Kelsey E Mauk, Neil J McKenna, Yichao Shen, Li-Zhen Song, Xiang H-F Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 220.5203 Modern versions and translations
• Thông tin xuất bản: United States : Science advances , 2025
• Bộ sưu tập: NCBI
• ID: 66756

Tóm tắt

Adaptive immunity is critical in eliminating tumors, but cancer-intrinsic factors can subvert this function. Melanoma antigen-A4 (MAGE-A4), a cancer-testis antigen, is expressed in solid tumors and correlates with poor survival, but its role in tumorigenesis and antitumor immunity remains unclear. We found that expression of MAGE-A4 was highly associated with the loss of