PURPOSE: Comprehensive analysis of serum lipidomics is important for the treatment and prevention of type 2 diabetes (T2DM). The purpose of this study was to provide a profile of lipid changes in the serum of T2DM patients and identify potential lipid biomarkers. PATIENTS AND METHODS: In this study, we collected clinical physiological parameters and determined the serum lipid profiles of 30 T2DM patients and 30 matched healthy volunteers using the UPLC-MS method. RESULTS: Based on the above test, 1162 lipid metabolites were detected, of which 267 were significantly altered in the T2DM group (FDR <
0.05), which belonged to the five main lipid classes. Eleven lipids were identified as potential lipid biomarkers with the specific screening criteria (variable importance in the projection (VIP) >
1.0
P <
0.05
log CONCLUSION: The results of this study revealed important changes in lipids in T2DM patients, expanded the knowledge of lipid levels and T2DM progression, and provided important metabolic information for the therapy and diagnosis of T2DM.