BACKGROUND: The main carrier protein of vitamin D and its metabolites in plasma is vitamin D binding protein (VDBP) or group-specific component (Gc). Two single nucleotide polymorphisms, rs7041, and rs4588 in the METHODS: The genomic DNA was isolated from blood samples of drug-naïve MS patients ( RESULTS: The study detected four Gc genotypes/phenotypes, namely CONCLUSION: The VDBP/GC genotypes and phenotypes are associated with MS. Common genotype