Cell-cell junctional proteins in cancer.

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Tác giả: Aparajita Das, Pubali Dey, Sarbani Giri

Ngôn ngữ: eng

Ký hiệu phân loại: 070.48346 Journalism

Thông tin xuất bản: United States : Advances in clinical chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 672918

A hallmark change during carcinogenesis is disruption or dysregulation of cell-cell junctions. It enables a transformed cell to adopt mesenchymal phenotype and acquire higher potential to migrate and invade. This ultimately leads to cancer metastasis. During this process, junctional proteins undergo remarkable changes in terms of their expressional pattern, localization, and activity. De-localized junctional proteins may adopt atypical roles which might act to either suppress tumorigenesis or facilitate cancer development, depending on several factors. In this chapter, the authors attempt to know the expression pattern of junctional proteins in different types of cancer, understand its significance, and gather knowledge about the mechanisms by which they regulate tumorigenesis and cancer development.
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