Các chỉ dấu sinh hóa hiện tại và mới liên quan ung thư biểu mô tế bào gan

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Tác giả: Tấn Đạt Hồ, Thị Thu Thủy Phạm

Ngôn ngữ: vie

Ký hiệu phân loại: 574.1 [Unassigned]

Thông tin xuất bản: Tạp chí Y dược lâm sàng 108, 2022

Mô tả vật lý: 28-35

Bộ sưu tập: Metadata

ID: 673605

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HCC was ranked as the sixth most common cancer in the world and was the fourth leading cause of cancer-related deaths. Thereforethe early diagnosis of HCC is essential for the most effective treatments and early detection of recurrence in order to increase the patients’ chances of survival. In addition to imaging devices such as ultrasoundCTand MRIbiomarkers increasingly play a role in the early diagnosis of HCC. They help to predict hepatocellular carcinoma in cases of chronic hepatitis BC or cirrhosisto monitor patients after treatment and to detect recurrences. Along with AFP and AFP-L3PIVKA II has been widely applied in early HCC detectionas this method provides the best diagnostic result with AUROC at 0.86. With the growing trend of applying markers in early cancer diagnosisa number of markers continue to be launched such as M2BPGiHBcrAgAKR1B10AXLGP73GPC3etc. Among them M2BPGi and HBcrAg have been used in Viet Nam and they prove to be valuabe in
HBV- related HCC management. Every technique and biomarker used to diagnose HCC has their advantages and disadvantages. So it is necessary to know how to use each of them properlyaccuratelyand effectively.Ung thư biểu mô tế bào gan đứng hàng thứ sáu trong các ung thư hay gặp trên thế giới và là nguyên nhân thứ tư gây tử vong do ung thư. Vì vậy vấn đề chẩn đoán sớm ung thư thật cần thiết giúp cho hiệu quả điều trị tốt nhất và phát hiện sớm tái phát làm tăng cơ hội sống còn cho bệnh nhân. Ngoài các phương tiện chẩn đoán hình ảnh như: Siêu âmchụp cắt lớp vi tính (CT)chụp cộng hưởng từ (MRI)các dấu ấn sinh học ngày càng tỏ ra có vai trò trong chẩn đoán ung thư sớmgiúp tiên đoán ung thư gan trong các trường hợp viêm gan BC mạn tính (CHBCHC) hay xơ gangiúp theo dõi sau điều trị và phát hiện tái phát. Xét nghiệm AFPAFP-L3PIVKA II đã được ứng dụng nhiều trong việc phát hiện HCC sớmcho kết quả chẩn đoán tốt nhất với AUROC là 0,86. Theo xu hướng ngày càng phát triển các dấu ấn sinh hóa mới tiên đoán ung thư sớm tiếp tục ra đời: M2BPGiHBcrAgAKR1B10AXLGP73GPC3… Trong đó M2BPGiHBcrAg đã được sử dụng ở Việt Nam tỏ ra có giá trị trong quản lý HCC liên quan virus viêm gan B. Do vậy mỗi kỹ thuậtmỗi dấu ấn sinh học để chẩn đoán HCC đều có ưu và khuyết điểm khác nhau nên phải biết để xử dụng cho hợp lýchính xác và hiệu quả.

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