Cập nhật các biến thể mô bệnh học của ung thư biểu mô tế bào gan

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Tác giả: Thị Huyên Đào, Thị Minh Hạnh Ngô

Ngôn ngữ: vie

Ký hiệu phân loại: 588.3 *Hepatopsida (Liverworts)

Thông tin xuất bản: Tạp chí Y dược lâm sàng 108, 2022

Mô tả vật lý: 48-55

Bộ sưu tập: Metadata

ID: 673632

Thêm vào giỏ

Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and South-East Asia nations. HCC related to the pathogenesis of hepatitis Bhepatitis Cboth alcoholic and non-alcoholic steatohepatitis (continuing to increase due to the rise of obesity and diabetes rate). Althoughthere are lot of progresseshowevertumor recurrencedistant metastasis and chemotherapy resistance remain mainly barrier in treatment of HCC. The advances in gene mutation researchmolecular targeted therapy is developing as a new hope for better disease control. Histologic classification of tumors according to World Heath Organization has been widely applied and practiced worldwide. The fifth modified and supplemented classification for primary tumors in liver was given histological subtypes of HCC that related to molecular characteristics. Further understanding on subtypes of HCC such as macrotrabecular massive HCCfibrolamellar HCClympho rich HCC... accompaning
with molecular changes of the primary liver tumor will bring value for prognosis and contribute to better HCC managementUng thư biểu mô tế bào gan là một trong 6 loại ung thư thường gặp nhất trên thế giới và khu vực Đông Nam Á. Ung thư biểu mô tế bào gan thường có liên quan đến các bệnh gan mạn tính như viêm gan virus B và virus Cviêm gan mỡ hoá do rượu và không do rượu (vẫn đang tiếp tục tăng do tăng tỷ lệ béo phì và đái tháo đường). Mặc dù đã có nhiều tiến bộ nhưng tỷ lệ tái phátdi căn xa và kháng hoá trị vẫn là rào cản trong điều trị ung thư biểu mô tế bào gan. Những tiến bộ mới trong nghiên cứu gen và liệu pháp nhắm trúng đích phân tử là một hy vọng cho kiểm soát bệnh tốt hơn. Bảng phân loại mô bệnh học ung thư biểu mô tế bào gan của Tổ chức Y tế Thế giới được áp dụng rộng rãi và thực hành trên toàn cầu. Việc bổ sungsửa đổi trong phân loại lần thứ 5 đã thiết lập các biến thể ung thư biểu mô tế bào gan và có liên quan đến đặc điểm phân tử. Việc hiểu biết thêm về các biến thể như ung thư biểu mô tế bào gan thể bè lớnung thư biểu mô tế bào gan mỡ hoáung thư biểu mô tế bào gan giàu lympho bàoung thư biểu mô tế bào gan thể xơ cứngung thư biểu mô tế bào gan thể xơ lá... cùng với đặc điểm sinh học phân tử của ung thư gan nguyên phát có ý nghĩa tiên lượng và góp phần hướng dẫn quản lý bệnh tốt hơn

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