Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14.

• Tác giả: Carly Chang, Majid Ghassemian, George Gorrie, Sang Ryeul Lee, Yuliang Ma, Alexandra C Newton, Caila A Pilo, Amanda J Roberts, Susan S Taylor, Sarah A Wolfe
• Ngôn ngữ: eng
• Ký hiệu phân loại: 583.49 *Jualandales
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 673660

Tóm tắt

UNLABELLED: Spinocerebellar Ataxia Type 14 (SCA14) is an autosomal dominant neurodegenerative disease caused by mutations in the gene encoding protein kinase C gamma (PKCγ), a Ca SUMMARY: New mouse model of Spinocerebellar Ataxia Type 14 containing a clinically relevant mutation in PKCγ identified underlying drivers of the disease and neuroprotection in females.