Inhibition of MAPK signaling suppresses cytomegalovirus reactivation in CD34

• Tác giả: Vargab Baruah, Michael C Kelly, Benjamin A Krishna, Christine M O'Connor, Xu Qi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 152.1 Sensory perception
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 673674

Tóm tắt

Reactivation of latent human cytomegalovirus (CMV) can lead to severe complications in individuals with dysregulated immune systems. While antiviral therapies for CMV are approved, these compounds are limited by their toxicity and inability to specifically target the latent reservoir or prevent reactivation. Herein we show that CMV reactivation in Kasumi-3 cells, a CD34