A cheater founds the winning lineages during evolution of a novel metabolic pathway.

• Tác giả: Shelley D Copley, Lauren C Phillips, Leo M Rusch, Karl A Widney
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.8265 Nautical engineering and seamanship
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 673679

Tóm tắt

Underground metabolic pathways-leaks in the metabolic network caused by promiscuous enzyme activities and non-enzymatic transformations-can provide the starting point for emergence of novel protopathways if a mutation or environmental change increases flux to a physiologically significant level. This early stage in the evolution of metabolic pathways is typically hidden from our view. We have evolved a novel protopathway in Δ