Axonal Mechanotransduction Drives Cytoskeletal Responses to Physiological Mechanical Forces.

• Tác giả: Daniel Beaudet, Chloe Emerson, Oliver V Glomb, Adam G Hendricks, Zhuoyuan Li, Grace L Swaim, Yi Xie, Shaul Yogev
• Ngôn ngữ: eng
• Ký hiệu phân loại: 618.92012 Pediatrics and geriatrics
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 673722

Tóm tắt

Axons experience strong mechanical forces due to animal movement. While these forces serve as sensory cues in mechanosensory neurons, their impact on other neuron types remains poorly defined. Here, we uncover signaling that controls an axonal cytoskeletal response to external physiological forces and plays a key role in axonal integrity. Live imaging of microtubules at single-polymer resolution in a