Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition.

• Tác giả: Daxiang Cui, Zhenying Diao, Youcheng Liang, Yanlei Liu, Yong Liu, Qiaoyou Lu, Long Qiu, Jianbo Sun, Ting Yin, Dou Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.317 *Conversion and maintenance
• Thông tin xuất bản: England : Materials today. Bio , 2025
• Bộ sưu tập: NCBI
• ID: 673812

Tóm tắt

Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nanomedicines. Herein, a NIR-II-responsive nanoplatform was developed under bioinformatics guided to effectly inhibit HSP90 for enhanced synergistic mild-photothermal chemotherapy without any notable tissue damage. The nanoplatforms were assembled from NIR-II-responsive gold nanobipyramids (GNBs) combined with curcumin (Cur)