PURPOSE: To assess the non-inferiority of mean absolute prediction error (APE) of the Argos (Movu, a Santec company) compared with the IOL Master 700 (Carl Zeiss Meditec AG) and Lenstar LS900 (Haag-Streit AG) biometers utilizing the Barrett Universal II (BUII) formula for power calculations in short, medium, and long axial length eyes. METHODS: This was a retrospective chart review of prediction error from 3 biometers (Argos, IOLMaster 700, and Lenstar LS900). Biometer measurement order was determined using blocked randomization. Eligible charts were from eyes 50-85 years old, axial length between 20.00 mm and 30.00 mm, and had IOL implantation with the AcrySof IQ monofocal IOL (SN60WF) and AcrySof toric IOL (SN6AT3, SN6AT4). Preoperative planning was done with the BUII formula on all biometers, with a target of plano. The primary outcome measure was the mean absolute prediction error for each biometer using BUII. Specifically, the non-inferiority of Argos compared to the IOLMaster 700 and Lenstar LS900 using a non-inferiority margin of 0.25 D. RESULTS: The chart review identified 203 eyes from 123 patients. Mean APE for Argos overall and for each axial length group was non-inferior to that of IOLMaster 700 and Lenstar LS900. The overall mean APE was 0.25 ± 0.20 D for Argos compared to 0.25 ± 0.20 D for IOLMaster 700, and 0.25 ± 0.19 D for Lenstar LS900. The differences were not significant (p >
0.05). The percentages of eyes with APE 0.5 D or less were 90% for Argos, 89% for IOLMaster 700, and 89% for Lenstar LS900. The differences were not significant (p >
0.05). CONCLUSION: Overall mean APE was not significantly different with the Argos compared to IOLMaster 700 and Lenstar LS900 using the BUII formula, suggesting that the use of any of these devices can achieve good outcomes.